Lin Zhang


Ph.D., Professor
Department of Biochemical Engineering,
School of Chemical Engineering and Technology,
Tianjin University, Tianjin 300354, P. R. China.

Email: linzhang@tju.edu.cn

 
Education
Bachelor (B. Eng.) – 2003, Tsinghua University, Beijing, China (Chem. Eng.)
Doctor (Dr. Eng.) – 2008, Tsinghua University, Beijing, China (Chem. Eng.)
 
Research Interests

Research is focused on the regulation of interfacial behavior of proteins, and its application on protein adsorption, development of novel antithrombotic agents, and construction of vaccines and synergetic catalysis of multi-enzymes using virus-like particle.
 
Research Experience

2016.06-Present Professor, Sch. of Chem. Eng., Tianjin University.
2010.11-2016.06 Associate Professor, Sch. of Chem. Eng., Tianjin University.
2015.01-2016.01 Visiting Scholar, Dept. of Chem. Eng., University of Washington.
2008.08-2010.10 Post doctor, Sch. of Chem. Eng., Tianjin University.
2003.09-2008.07 Ph.D. candidate, Dept. of Chem. Eng., Tsinghua University.
2006.03-2006.09 Visiting researcher, University of California at Riverside, U.S.A.
2002.09-2003.07 Undergraduate, Dept. of Chem. Eng., Tsinghua University.

 
Projects
  1. Fabrication of novel multi-enzyme system from protein self-assembly and its synergetic catalysis in carbon dioxide utilization, supported by Natural Science Foundation of China (No. 91534119), 2016.1-2018.12, PI.
  2. Studies of High-Performance Self-Assembly Technology for Virus-like Particle, supported by the Key Program of Natural Science Foundation of Tianjin (Grant No. 13JCZDJC31100) , 2013.4-2016.3, PI.
  3. Exploring smart thrombolytic strategy by multi-scale molecular dynamics simulation, supported by National Natural Science Foundation of China (Grant No. 21006069), 2011.1-2013.12, PI.
  4. Interfacial behavior of protein molecules, supported by Innovation Foundation of Tianjin University, 2014.1-2015.12, PI.
  5. Molecular insight into thrombus formation and the rational design of inhibitors, supported by Innovation Foundation of Tianjin University, 2011.6-2012.6, PI.
  6. Multi-scale investigation on the interfacial behaviors of protein, supported by Innovation Foundation of Tianjin University, 2011.6-2012.6, PI.
  7. Exploring the interfacial and molecular mechanisms of hydrophobic charge induction displacement chromatography, supported by Innovation Foundation of Tianjin University, 2010.1-2011.12, PI.
  8. Molecular insight of hydrophobic charge induction chromatography: a molecular simulation study, supported by China Postdoctoral Science Foundation (Ministry of Education) (Grant No. 20080440679), 2008-2010, PI.
 
Publications
  1. Wenchao Zhang, Yan Sun, Lin Zhang*, Fabrication of High Efficient Silver Nanoparticle Catalyst Supported on Poly(glycidyl methacrylate)-polyacrylamide. Industrial & Engineering Chemistry Research, 2016, 55(48): 12398–12406.
  2. Chao Zhang, Lin Zhang*, Youcai Zhang, Na Sun, Shaoyi Jiang, Timothy J. Fujihara, Yan Sun*, Development of antithrombotic nanoconjugate blocking integrin α2β1-collagen interactions. Scientific Reports, 2016, 6, 26292.
  3. Lin Zhang, Linda HL Lua, Anton PJ Middelberg, Yan Sun, Natalie K. Connors*: Biomolecular Engineering of Virus-Like Particles Aided by Computational Chemistry Methods. Chemical Society Reviews, 2015, 44(23): 8608–8618.
  4. Wenchao Zhang, Yan Sun, Lin Zhang*: In Situ Synthesis of Monodisperse Silver Nanoparticles on Sulfhydryl-Functionalized Poly(glycidyl methacrylate) Microspheres for Catalytic Reduction of 4-Nitrophenol. Industrial & Engineering Chemistry Research, 2015, 54(25): 6480–6488.
  5. Wenchao Zhang, Lin Zhang*, Yan Sun: Size-Controlled Green Synthesis of Silver Nanoparticles Assisted by L-Cysteine. Frontiers of Chemical Science and Engineering, 2015, DOI 10.1007/s11705-015-1527-1.
  6. Linling Yu#, Lin Zhang#, Yan Sun*: Protein behavior at surfaces: Orientation, conformational transitions and transport. Journal of Chromatography A, 2015, 1382C: 118–134.
  7. Lin Zhang, Ronghong Tang, Shu Bai, Natalie K. Connors, Linda HL Lua, Yap P. Chuan, Anton PJ Middelberg, Yan Sun*: Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations. PLoS ONE, 2014, 9(9): e107313–12.
  8. Yanying Li, Xiaodan Liu, Xiaoyan Dong, Lin Zhang*, Yan Sun*: Biomimetic Design of Affinity Peptide Ligand for Capsomere of Virus-Like Particle. Langmuir, 2014, 30(28): 8500–8508.
  9. Lin Zhang, Yan Sun*: Biomimetic design of platelet adhesion inhibitors to block integrin α2β1-collagen interactions: I. Construction of affinity binding model. Langmuir, 2014, 30 (16): 4725–4733.
  10. Lin Zhang, Chao Zhang, Yan Sun*: Biomimetic design of platelet adhesion inhibitors to block integrin α2β1-collagen interactions: II. Inhibitor library, screening and experimental validation. Langmuir, 2014, 30 (16): 4734–4742.
  11. Xiaoyan Dong, Xiaodan Liu, Lin Zhang*, Intein-Mediated Expression and Purification of Murine Polyomavirus Virus-Like Particles, Journal of Tianjin University (Science and Technology) , 2014, 47(04): 315–320. (EI)
  12. Lin Zhang, Ronghong Tang, Shu Bai, Natalie K. Connors, Linda HL Lua, Yap P. Chuan, Anton PJ Middelberg, Yan Sun*, Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations. Journal of Physical Chemistry B, 2013, 117(18): 5411–5421. (SCI, 143TS, IF 3.603)
  13. Shu Bai, Hao Li, Lin Zhang*, Standing orientation of lysozymes induced by electrostatically repulsive surface, Acta Physico-Chimica Sinica, 2013, 29(4): 849–857. (SCI, 116EB, IF 0.869)
  14. Shu Bai, Ronghong Tang, Lin Zhang*, Molecular Dynamics Simulation of the Stability of Capsomere, Chemical Industry and Engineering, 2013, 30(6): 62–66.
  15. Lin Zhang, Yan Sun*, Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics simulations, Frontiers of Chemical Science and Engineering, 2013, 7(4): 456–463.
  16. Guangjie Han, Xiaoyan Dong, Lin Zhang*, Litang Fu, Guozhen Wang, Yan Sun*, Facilitated oxidative refolding of ribonuclease A from inclusion bodies with a new redox system, Biochemical Engineering Journal, 2012, 69 (15): 106–112. (SCI, 052DS, IF 2.692)
  17. Jian Li, Lin Zhang, Yan Sun*, Molecular basis of the initial platelet adhesion in arterial thrombosis: molecular dynamics simulations, Journal of Molecular Graphics and Modelling, 2012, 37: 49–58. (SCI, 969AD, IF 2.038)
  18. Guofeng Zhao, Lin Zhang*, Shu Bai, Yan Sun*, Analysis of hydrophobic charge induction displacement chromatography by visualization with confocal laser scanning microscopy, Separation and Purification Technology, 2011, 82: 138–147. (SCI, 845OD, IF 2.775)
  19. Lin Zhang, Shu Bai, Yan Sun*, Modification of Martini force field for molecular dynamics simulation of hydrophobic charge induction chromatography of lysozyme, Journal of Molecular Graphics and Modelling, 2011, 29(7): 906–914. (SCI, 774VL, IF 2.038)
  20. Lin Zhang, Guofeng Zhao, Yan Sun*, Effects of ligand density on hydrophobic charge induction chromatography: a molecular dynamics simulation. Journal of Physical Chemistry B, 2010, 114 (6): 2203–2211. (SCI, 553GV, IF 3.603)
  21. Lin Zhang, Shu Bai, Yan Sun*, Molecular dynamics simulation of the effect of ligand homogeneity on protein behavior in hydrophobic charge induction chromatography, Journal of Molecular Graphics and Modelling, 2010, 28(8): 863–869. (SCI, 606HY, IF 2.038)
  22. Lin Zhang, Yan Sun*, Molecular simulation of adsorption and its implications to protein chromatography: a review. Biochemical Engineering Journal, 2010, 48 (3): 408–415. (SCI, 576CO, IF 2.692)
  23. Lin Zhang, Guofeng Zhao, Yan Sun*, Molecular dynamics simulation and experimental validation for the effect of pH on protein desorption in hydrophobic charge induction chromatography, Molecular Simulation, 2010, 36(13): 1096–1103. (SCI, 685KP, IF 1.215)
  24. Lin Zhang, Guofeng Zhao, Yan Sun*, Molecular insight into protein conformational transition in hydrophobic charge induction chromatography: a molecular dynamics simulation, Journal of Physical Chemistry B, 2009, 113(19): 6873–6880. (SCI, 443CP, IF 3.603)
  25. Lin Zhang, Diannan Lu, Zheng Liu*, Dynamic control of protein conformation transition in chromatographic separation based on hydrophobic interactions: Molecular dynamics simulation, Journal of Chromatography A, 2009, 1216(12): 2483-2490. (SCI, 419KH, IF 4.194)
  26. Lin Zhang, Diannan Lu, Zheng Liu*, How native proteins aggregate in solution: a dynamic Monte Carlo simulation, Biophysical Chemistry. 2008, 133(1-3): 71-80. (SCI, 268ZQ, IF 2.108)
  27. Lin Zhang, Diannan Lu, Zheng Liu*, Dynamic Monte Carlo simulation on protein aggregation and its inhibition by polymer, Journal of Chemical Industry and Engineering(China), 2008, 59(01), 153-159. (EI, 080811110678)
  28. Lin Zhang, Diannan Lu, Zheng Liu*, The effect of urea on the conformational transition of protein in aqueous by molecular dynamics simulations, Chinese Journal of Bioprocess Engineering, 2006, 4(03), 38-43.