4. VLP-Based Multi-enzyme System

Synergetic catalysis of multi-enzymes is one of the key issues for improving the efficiency of many chemical reactions, such as the conversion of carbon dioxide to methanol for carbon capture and utilization. Virus-like particle (VLP) is a highly organized nanoparticle that self-assembles from viral structural proteins, providing well-arranged reaction sites for controllable combination of different enzyme molecules. Hence, it is preferred for the construction of synergetic catalysis of multi-enzymes. We are currently investigating the fabrication of novel multi-enzyme system to realize the synergetic catalysis in carbon dioxide utilization, based on the research into the self-assembly of VLP and its regulation mechanism.