Lin-Ling Yu


Ph.D., Associate Professor
Department of Biochemical Engineering,
School of Chemical Engineering and Technology,
Tianjin University, Tianjin 300354, P. R. China.

Email: yulinling@tju.edu.cn

 
Education
Bachelor (B. Eng)– 2008, Tianjin University, Tianjin, China (Bio. Eng.)
Master (M. Eng) – 2010, Tianjin University, Tianjin, China (Biochem. Eng.)
Doctorate (Dr. Eng.) – 2013, Tianjin University, Tianjin, China (Biochem. Eng.)
 
Employment

2020 – Present        Associate Professor, Dept. Chem. Eng., Tianjin University

2013 – 2020        Lecturer, Dept. Chem. Eng., Tianjin University

 
Research Interests

Protein chromatography
Enzyme modification/immobilization
Nanomotor

 
Teaching Activities

1. Biotechnology
2. Biochemistry
3. Biochemistry Experiments
4. Advance in Biotechnology

 
Projects

1. Design of smart nanomotor carrier for mucosal penetrating drug delivery and its regulation and intensification [21878223]
2. Molecular mechanisms of oxysterol in the aggregation of amyloid protein and the inhibition of aggregation inhitors [21406160]
3. Design of acid-sensitive micro/nano-carrier for infrared-driven drug delivery and intensification of its diffusion and transmembrane process [19JCQNJC05200]
4. Molecule behaviors of protein at surface[2017XRG-0056]

 
Publications
  1. L-L Yu, Y Sun*: Recent advances in protein chromatography with grafted polymeric ligands. Journal of Chromatography A. 2021, 1638: 461865.
  2. L-L Yu#, C-S Li#, Y Liu, Y Sun*: Protein adsorption to poly(2-aminoethyl methacrylate)-grafted Sepharose FF: Effects of chain length and charge density. Journal of Chromatography A. 2021, 1638: 461869.
  3. L-L Yu#, R Xu#, X-Y Dong, Y Liu, Y Sun*: Protein adsorption to (3-acrylamido propyl) trimethyl ammonium chloride-grafted Sepharose gel: Charge density reduction via copolymerizing with electroneutral monomer drastically increases uptake rate. Journal of Chromatography A. 2020, 1629: 461843.
  4. L-L Yu, Q-H Zhai, Y Sun*: Protein adsorption to poly(ethylenimine)-modified Sepharose FF: VIII. Impacts of surface ion-exchange groups at different polymer grafting densities. Journal of Chromatography A. 2020, 1610: 460538.
  5. D-T Han, S Bai, L-L Gong, L-L Yu*, Y Sun: Effect of counterions on protein adsorption and elution of DEAE-dextran modified Sepharose FF. Chemical Industry and Engineering Progress. 2018, 37 (1): 260–268.
  6. Y-Y Zhao#, L-L Yu#, X-Y Dong, Y Sun*: Protein adsorption to poly(ethylenimine)-modified Sepharose FF: VII. Complicated effects of pH. Journal of Chromatography A. 2018, 1580: 72–79.
  7. S Bai, L-L Gong, D-T Han, Y-T Li, L-L Yu*, Y Sun: Protein adsorption onto diethylaminoethyl dextran modified anion exchanger: Effect of ionic strength and column behavior. Chinese Journal of Chemical Engineering. 2018, 26: 259–267.
  8. Q-H Zhai, L-L Yu*, Y Sun: Effect of counterions on protein adsorption to partial neutralization poly(ethylenimine)-grafted Sepharose FF. CIESC Journal. 2017, 68 (11): 4178−4185.
  9. L-L Yu, L-L Gong, S Bai, Y Sun*: Surface DEAE groups facilitate protein transport on polymer chains in DEAE-modified-and-DEAE-dextran-grafted resins. AIChE Journal. 2016, 62(10): 3812-3819.
  10. L-L Yu, Y Sun*: Adsorptive protein chromatography with grafted polymeric ligands. CIESC Journal. 2016, 67 (1): 140-151.
  11. L-L Yu#, N Liu#, Y Hong, Y Sun*: Protein adsorption and chromatography on novel mixed-mode resins fabricated from butyl-modified poly(ethylenimine)-grafted Sepharose. Chemical Engineering Science. 2015, 135: 223–231.
  12. L-L Yu, L Zhang, Y Sun*: Protein behavior at surfaces: Orientation, conformation transitions and transport. Journal of Chromatography A (Review, Editors' choice issue). 2015, 1382: 118–134.
  13. Y Hong, N Liu, W Wei, L-L Yu*, G Ma, Y Sun*: Protein adsorption to poly(ethylenimine)-modified Sepharose FF: Ⅲ. Comparison between different proteins. Journal of Chromatography A. 2014, 1342 (1): 30–36.
  14. N Liu, Z-Y Wang, L-L Yu*, Y Sun*: Characterization of novel mixed-mode protein adsorbents fabricated from benzoyl-modified polyethyleneimine-grafted Sepharose. Journal of Chromatography A. 2014, 1372, 157–165.
  15. L-L Yu, S-P Tao, X-Y Dong, Y Sun*: Protein adsorption to poly(ethylenimine)-modified Sepharose FF: I. A critical ionic capacity for drastically enhanced capacity and uptake kinetics. Journal of Chromatography A. 1305 (2013) 76–84.
  16. L-L Yu, Y Sun*: Protein adsorption to poly(ethylenimine)-modified Sepharose FF: II. Effect of ionic strength. Journal of Chromatography A. 1305 (2013) 85–93.
  17. L-L Yu, X-Y Dong, Y Sun*: Ion-exchange resins facilitate like-charged protein refolding: Effect of porous solid phase properties. Journal of Chromatography A. 2012, 1225 (1): 168-173.
  18. L-L Yu, Y Sun*: Trace adsorption of positively charged proteins onto Sepharose FF and Sepharose FF-based anion exchangers. Journal of Chromatography A. 2012, 1253 (1): 105– 109.
  19. L-L Yu, Q-H Shi*, Y Sun*: Effect of dextran layer on protein uptake to dextran-grafted adsorbents for ion-exchange and mixed-mode chromatography. Journal of Separation Science. 2011, 34 (21): 2950-2959.