Fufeng Liu


Ph.D., Associate Professor
Department of Biochemical Engineering,
School of Chemical Engineering and Technology,
Tianjin University, Tianjin 300072, P. R. China.

Email: fufengliu@tju.edu.cn

 
Education
1998.09-02.07 Chemistry & Biology College, Yantai University, B.S.
2003.09-05.08 Dept. Chem. Eng., Tianjin University, M.S.
2005.09-08.09 Dept. Chem. Eng., Tianjin University, Ph. D.
 
Employment

2011.06-present Associate Professor, Dept. Chem. Eng., Tianjin University.
2008.12-2011.05 Lecturer, Dept. Chem. Eng., Tianjin University.
2002.07-2003.08 Technician, Yichang Fine Chemical Factory of Fushan Distict

 
Research Area

Affinity Chromatography:

- Rational design of affinity peptide ligand
- The mechanism of affinity chromatography using MD simulations

Protein Stability and Aggregation:

- Peptide folding and stability
- Amyloid peptide aggregation

 
Foundings
  1. National Natural Science Foundation of China (20906068) Studies on the molecular mechanism for protein stabilization by hydroxyl osmolytes, 200,000, 2010.01-2012.12
  2. Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission, China (10JCYBJC04500) Rational design and high throughput screening of affinity peptide ligand, 100,000, 2010.04-2013.03.
  3. Independent Innovation Foundation of Tianjin University, China Molecular mechanisms of the multi-drug resistance caused by P-glycoprotein and its inhibition, 50,000, 2010.01.01-2011.12.31
 
Publications
  1. B. Huang, F.-F. Liu*, X.-Y. Dong, Y. Sun*. Comparative Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations, The Journal of Physical Chemistry B, DOI:10.1021/jp205770p.
  2. F.-F. Liu, X. –Y. Dong, L. Z. He, A. P. J. Middelberg, Y. Sun*: Molecular Insight into Conformational Transition of Amyloid beta-Peptide 42 Inhibited by (-)-Epigallocatechin-3-gallate Probed by Molecular Simulations. The Journal of Physical Chemistry B, 2011, 115, 11879-11887. SCI: 831AI
  3. B. Huang, F.-F. Liu, X.-Y. Dong, Y. Sun*. Molecular Mechanism of the Affinity Interactions between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations. The Journal of Physical Chemistry B, 2011, 115, 4168-4176.
  4. S.-H. Wang, F.-F., Liu, X.-Y. Dong, Y. Sun*. Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (-)-Epigallocatechin-3-gallate. The Journal of Physical Chemistry B, 2010, 11576-11583.
  5. F.-F. Liu, L. Ji, X.-Y. Dong*: Effects of molecular volume and fractional polar surface area of osmolytes on protein thermal stability. Acta Phys. Chim. Sin., 2010, 26 (10):2813-2820.
  6. F.-F. Liu, X.-Y. Dong, Y. Sun*: Molecular Dynamics Simulation on Conformational Transition of Amyloid Peptide 42 Inhibited by Trehalose. Acta Phys. Chim. Sin., 2010, 26(6):1643-1650.
  7. F.-F. Liu, J. Luo, L. Zhang, X.-Y. Dong, Y. Sun*: Molecular basis for polyol-induced protein stability revealed by molecular dynamics simulations. Journal of Chemical Physics, 2010, 132: 225103.
  8. F.-F. Liu, J. Luo, X.-Y. Dong, Y. Sun*: BIOT 146-Molecular dynamics simulation of the inhibition effect of trehalose on the nucleation and elongation of amyloid beta-peptide oligomers. Abstracts of papers of the American Chemical Society, Vol: 238, 146-BIOT, Aug 16 2009. SCI: V16HY
  9. F.-F. Liu, J. Luo, X.-Y. Dong, Y. Sun*: Molecular insight into the inhibition effect of trehalose on the nucleation and elongation of Amyloid β-peptide oligomers. The Journal of Physical Chemistry B, 2009, 113 (32): 11320-11329.
  10. X.-Y. Dong, J.-H. Liu, F.-F. Liu, Y. Sun*: Self-interaction of native and denatured Lysozyme in the presence of osmolytes, L-arginine and guanidine hydrochloride. Biochemical Engineering Journal, 2009, 43: 321-326.
  11. Y. Sun*, F.-F. Liu, Q.-H. Shi: Approaches to high-performance preparative chromatography of proteins, Advances in Biochemical Engineering /Biotechnology, 2009, 113: 217-254.
  12. F.-F. Liu, X.-Y. Dong, Y. Sun*: Molecular mechanism for the effects of trehalose on β-hairpin folding revealed by molecular dynamics simulation. Journal of Molecular Graphics and Modelling, 2008, 27 (4): 421-429.
  13. F.-F. Liu, Y. Sun*: Discovery and design of affinity ligands for protein chromatography. Journal of Biotechnology, 2008, 136: S469.
  14. F.-F. Liu, X.-Y. Dong, T. Wang, Y. Sun*: Rational design of peptide ligand for affinity chromatography of tissue-type plasminogen activator by the combination of docking and molecular dynamics simulations. Journal of Chromatography A, 2007, 1175 (2): 249-258.
  15. F.-F. Liu, T. Wang, X.-Y. Dong, Y. Sun*: Rational design of affinity peptide ligand by flexible docking simulation. Journal of Chromatography A, 2007, 1146 (1): 41–50.