Professor Bai-Shan Fang Gave An Academic Report Online
 

    At the invitation of LIMB, Professor Baishan Fang from Xiamen University gave an online academic report on "Exploring new mechanisms of oxidoreductase catalysis" for faculty and students of the Department of Biochemical Engineering on April 11th, 2023. Professor Yan Sun presided over the report meeting. Through the study of enzyme catalysis at the single-molecule scale, Professor Fang and his group found that the catalytic mechanism of formate dehydrogenase (FAD) didn't follow the traditional theorell-chance mechanism. It is proposed that coenzyme dependent oxidoreductase binds to its coenzyme through self-assembly, and the bound NADH is directly converted into NAD+ through in situ hydride transfer reaction, which is expected to establish a new catalytic mechanism for coenzyme dependent oxidoreductase.